York College has over 60 undergraduate majors including but not limited to Accounting, Aviation Management, Black Studies, Anthropology, Art History, Art (Painting, Drawing, Sculpture), Biology, Biotechnology, Business Administration, Chemistry, Communications Technology, Computer Science, Economics, English, Movement Science, Music, Nursing, Physics, Psychology, Social Work, Speech Communication and Theater Arts, and Teacher Education.

The College also offers the following graduate programs: MS in Pharmaceutical Science and Business, MS in Clinical Trial Management, MS in Aviation Management, MS in Physician Assistant, MS in Nursing Education, the Master of Science in Social Work (MSW), and one combined program in Occupational Therapy (BS/MS).